Escape From the Endosome

Pfizer and Moderna’s COVID-19 vaccines have demonstrated just how useful large biomolecule drugs can be. Their vaccines are based on RNAs which are hundreds of times bigger than a typical small-molecule drug. UConn associate professor of biomedical engineering Dr. Yupeng Chen, his student Jinhyung Lee, and other members of his lab describe in the May 11 issue of PNAS a way to protect large biomolecule drugs by encasing them in a nanomaterial mimicking DNA.

Please read the paper at:

https://www.pnas.org/content/118/19/e2104511118

and the full story at:

https://phys.org/news/2021-05-endosome-approach-valuable-medicines.html and

https://today.uconn.edu/2021/05/escape-from-the-endosome/