Date of Event Nov 30 2023
Start Time 11:00 AM
End Time 12:00 PM
Eben Alsberg, Ph.D.
Richard and Loan Hill Chair Professor
of Biomedical Engineering, Orthopaedics, Pharmacology and Regenerative
Medicine, and Mechanical and Industrial Engineering
Director, Alsberg Stem Cell and Engineered Novel Therapeutics Laboratory
University of Illinois at Chicago
Engineering scaffold-free tissue constructs via modular assembly, cell-only bioprinting and 4D strategies
Abstract: Many tissues form and heal through the initial formation of a condensation of cells. Scaffold-free tissue engineering aims to partially mimic these processes. Traditional scaffold-free tissue engineering has focused primarily on cell condensations in the form of simple spheres or sheets. In this talk, three technologies enabling the biofabrication of more complex cell condensation tissue architectures and organizations will be presented. In the 1st technology, hydrogel molds are used to form modular cell condensation tissue building blocks that may then be assembled to form multi-tissue organs. the 2nd technology involves a platform system for bioprinting cell-only bioinks in complicated structures. Finally, the 3rd technology permits the formation of 4D high cell density and cell condensation constructs that can change their shape over time.
Biography: Eben Alsberg holds the Richard and Loan Hill Chair Professorship in the Departments of Biomedical Engineering, Orthopaedics, Pharmacology and Regenerative Medicine, and Mechanical and Industrial Engineering at the University of Illinois at Chicago, where he serves as Director of the Alsberg Stem Cell and Engineered Novel Therapeutics (ASCENT) Laboratory. He was previously a professor at Case Western Reserve University in the Departments of Biomedical Engineering and Orthopaedic Surgery
from 2005-2018. He received his B.S.E. in Biomedical Engineering and also in Mechanical Engineering and Material Science from Duke University in 1994. He then went to graduate school at the University of Michigan, Ann Arbor, where he received an M.S.E. in Mechanical Engineering (1998), an M.S.E. in Biomedical Engineering (1998), and a Ph.D. in Biomedical Engineering (2002). Following his graduate studies, he was a Postdoctoral Research Fellow in the Vascular Biology Program at Harvard Medical School. His laboratory focuses on engineering functional biologic replacements to repair damaged or diseased tissues in the body. Complex signals implicated in tissue morphogenesis, repair, and homeostasis are used as inspiration for the development of innovative biomaterials for tissue regeneration. Through the precise temporal and spatial presentation of soluble bioactive factors, mechanical forces, and biomaterial
physical and biochemical properties, his lab aspires to create microenvironments that regulate cell gene expression and new tissue formation. He has co-authored >155 peer reviewed papers and book chapters, and his work has been recognized with the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Senior Scientist Award, the Biovalley Young Investigator Award from the Tissue Engineering Society International (TESI), the Ellison Medical Foundation New Scholar in Aging Award, the Crain’s Cleveland Business Forty Under 40 Award, the Technion Lady Davis Fellowship, a Visiting Professorship at Kyung Hee University, and election as fellow of the National Academy of Inventors (NAI), the American Institute for Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES). His research has been funded by the NIH, DOD, NSF, the Ellison Medical Foundation,
the Coulter Foundation, the Musculoskeletal Transplant Foundation, the State of Ohio and the AO Foundation. Alsberg has ~35 patents issued or pending in the field of tissue engineering. He has given >160 invited lectures around the world and is active in many professional societies.
If you are unable to attend in person you can join in remotely on WebEx here
Date Published: May 04, 2023