Escape From the Endosome

Pfizer and Moderna’s COVID-19 vaccines have demonstrated just how useful large biomolecule drugs can be. Their vaccines are based on RNAs which are hundreds of times bigger than a typical small-molecule drug. UConn associate professor of biomedical engineering Dr. Yupeng Chen, his student Jinhyung Lee, and other members of his lab describe in the May 11 issue of PNAS a way to protect large biomolecule drugs by encasing them in a nanomaterial mimicking DNA.

Please read the paper at:

and the full story at: and


UConn Research will Go into Space!

Prof. Yupeng Chen has received a grant titled: “Engineering Multiple-Compartment Cartilage Tissue Construct for Space and Terrestrial Applications” to develop tissue constructs using DNA-inspired Janus base nanotubes in the International Space Station.

This is a multi-agency grant including $400,000 to UConn from NSF and $415,000 to SpaceTango (the implementation partner) from CASIS and NASA. NASA will also cover the cost and resources to launch the experiment into Space via a SpaceX Falcon-9 rocket in 2022.

Profs. Chen and Chon Received NIH Grant to Develop Smartphone Sensor to Detect Tooth Pain

Drs. Ki Chon (right) and I-Ping Chen (left) received a new R21 grant from NIH.  Dr. I-Ping Chen is a Dental Medicine faculty at UConn Health.  This is a multi-PI collaborative grant which will investigate a novel approach to quantify dental pain.  The grant is entitled “Quantitative assessment of dental pain using a smartphone-attachable electrodermal activity sensor.”  The grant is for 2 years (6/1/2020-5/30/2022) and the amount is $462,964.

Leila Daneshmandi recognized by Women of Innovation

Leila Daneshmandi, a Ph.D. candidate in our Biomedical Engineering Department, is the 2020 finalist in the category of Collegian Innovation and Leadership women of innovation. This is a great honor and accomplishment to be selected among 150 nominations. For more information, please check links below:


Dr. Kazunori Hoshino was awarded a CAREER award from the NSF

Dr. Kazunori Hoshino was awarded a CAREER award from the NSF. His grant is entitled “Biomechanical Signatures in Vertebrate Embryonic Development.” The duration and amount of this award are 5 years and $500K, respectively.

Prof. Hoshino is BME’s 5th CAREER recipient in the past 3 years. The other recipients are Profs. Pierce, Feng, Santaniello and Chen.

UCONN BME Senior Design 2019-2020