Escape From the Endosome

Pfizer and Moderna’s COVID-19 vaccines have demonstrated just how useful large biomolecule drugs can be. Their vaccines are based on RNAs which are hundreds of times bigger than a typical small-molecule drug. UConn associate professor of biomedical engineering Dr. Yupeng Chen, his student Jinhyung Lee, and other members of his lab describe in the May 11 issue of PNAS a way to protect large biomolecule drugs by encasing them in a nanomaterial mimicking DNA.

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