Research Summary:

     Dr. Han’s research focuses on: (1) the development of advanced microelectrode technologies for neuromodulation and neuroprosthesis for treatment of neurological diseases, and (2) understanding the fundamental science behind the interface of the brain and microelectrode materials. His current effort includes developing a silicon-based microelectrode technology to convey sound to persons with auditory nerve damaged by implanting the device in their cochlear nucleus in the brainstem. This effort is now in translational stage. Another project is to expand and share utility of his team’s devices to other research labs around the country by custom-assembling silicon-based 3D multisite microelectrode arrays for targets in the cerebral cortex, deep brain, brainstems, and spinal cord and nerves. He is also interested in understanding the interface between the brain tissues and microelectrodes. He has been awarded several NIH and Dept. of Defense DARPA grants, and serves in NIH study sections.

Selected Publications:

1. Duong, H. and Han, M. (2013). “A multispectral LED light apparatus for the reduction of background autofluorescence in brain tissue,” Journal of Neuroscience Methods. 220(1): 46-54. DOI: 10.1016/ j.jneumeth.2013.08.018
2. McCreery, D.B., Han, M., Pikov, V., and Pannu, S. (2013). “Encoding of the amplitude modulation of pulsatile electrical stimulation in the feline cochlear nucleus by neurons in the inferior colliculus; Effects of stimulus pulse rate.” Journal of Neural Engineering. 10 (17): 056010.
3. Han, M., P. S. Manoonkitiwongsa, C. X. Wang, and D. B. McCreery (2012). “In-Vivo Validation of Custom-Designed Silicon-Based Microelectrode Arrays for Long-term Neural Recording and Stimulation,” IEEE Transactions in Biomedical Engineering. 59(2): 346-54.
4. McCreery, D. B., Han, M., and Pikov, V. (2010). “Neuronal activity evoked in the inferior colliculus of the cat by surface macroelectrodes and penetrating microelectrodes implanted in the cochlear nucleus”. IEEE Transactions in Biomedical Engineering. 57(7): 1765-1773. 
5. Sharma, V. McCreery, D. B., Han, M., and Pikov, V. (2010). “Wireless Bidirectional Telemetry Controller for Neuroprosthetic Devices”. IEEE Transactions On Neural Systems And Rehabilitation Engineering 18(1): 67-74.
6. (*contributed equally) Gholmieh, G.*, Soussou, W.*, Han, M.*, Ahuja, A., Hsiao, M.-C., Song, D., Tanguay, A. R., Jr. and Berger, T. W. (2006). “Custom-designed high-density conformal planar multielectrode arrays for brain slice electrophysiology.” Journal of Neuroscience Methods 152(1-2): 116-129.

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