Hoshino, Kazunori

Kazunori Hoshino, Ph.D.
Associate Professor, Biomedical Engineering
Research Interests:  
Nano/micro-electro-mechanical systems (NEMS/MEMS); detection, imaging and analysis of cancer cells; nano and micro scale mechanical sensing and optical imaging.
260 Glenbrook Rd Unit 3247
University of Connecticut
Storrs, CT 06269-3247
Office Phone:   860-486-4294
Office Fax:   860-486-2500
BS University of Tokyo MS University of Tokyo Ph.D. University of Tokyo

Research Summary:

He studies nano/micro-electro-mechanical systems (NEMS/MEMS) for biomedical applications. The two focus areas are: (1) Nano and microscale mechanical sensing and optical imaging. Microfabricated mechanical sensors and actuators are strong tools for biomedical analysis. He has created several types of micro-scale mechanical manipulators for the analysis of live microtissues and cells. He integrates his expertise in image analysis and numerical analysis to open up a unique research area, namely microscale robotics for tissue engineering. (2) Detection and analysis of cancer cells. He investigates smart microfluidic systems to capture and analyze cancer cells. He developed a system that successfully separated cancer cells from clinical blood samples of patients with breast, prostate, colon, and lung cancer.
He co-authored a textbook, Molecular Sensors and Nanodevices, from Elsevier (1st edition in 2013, 2nd edition in 2018), and has more than 110 peer-reviewed publications. He is the inventor of 6 US patents and 12 Japanese patents.

More information can be found on my website

Honors and Awards:
  • NSF-CAREER award
  • NSF-CCSS (Communications, Circuits, and Sensing-Systems) award
  • NEDO (the New Energy and Industrial Technology Development Organization of Japan) Industrial Technology Research Grant
  • MEXT (Ministry of Education, Culture, Sports, Science and Technology in Japan) grant
  • JSPS (the Japan Society for the Promotion of Science) grant
Selected Publications:

Google Scholar Citations Link

  1. Ariane Garrett, Garrett J. Soler, Michael L. Diluna, Ryan A. Grant, Hitten P. Zaveri, and Kazunori Hoshino, “A Passive, Biocompatible Microfluidic Flow Sensor to Assess Flows in a Cerebral Spinal Fluid Shunt,” Sensors and Actuators A, 312, 112110, 2020.
  2. Devina Jaiswal, Zoe Moscato, Yuji Tomizawa, Kevin P. Claffey, and Kazunori Hoshino, “Elastography of multicellular spheroids using 3D light microscopy,” Biomedical Optics Express 10(5), 2409-2418, 2019.
  3. Garrett J. Soler, Mengdi Bao, Devina Jaiswal, Hitten P. Zaveri, Michael L. DiLuna, Ryan A. Grant, and Kazunori Hoshino, “A Review of Cerebral Shunts, Current Technologies and Future Endeavors,” Yale Journal of Biology and Medicine, 91(3): 313–321, 2018.
  4. Devina Jaiswal, Min D. Tang-Schomer, Disha Sood, David L. Kaplan, and Kazunori Hoshino, “Non-destructive, Label-free Characterization of Mechanical Micro-heterogeneity in Biomimetic Materials,” ACS Biomaterials Science & Engineering 4(9), 3259-3267, 2018.
  5. Devina Jaiswal, Norah Cowley, Zichao Bian, Guoan Zheng, Kevin P. Claffey, and Kazunori Hoshino, “Stiffness Analysis of 3D Spheroids using Microtweezers,” PLoS ONE 12(11): e0188346, 2017.