John Denis Enderle, Ph.D.
Professor & University of Connecticut Teaching Fellow
Biomedical Engineering, and Electrical and Computer Engineering
Physiological Modeling, Bioinstrumentation, Clinical Engineering, Oculomotor System and Neurosensory Control
Room 209, 260 Glenbrook Road
University of Connecticut
Storrs, CT 06269-3247
Office Phone: (860) 486-5521
Office Fax: : (860) 486-2500
BS Rensselaer Polytechnic Institute
ME Rensselaer Polytechnic Institute
PhD Rensselaer Polytechnic Institute
My primary research thrust throughout most of my career has been the study of muscle mechanics and the oculomotor system, applied to the human visual and auditory systems. This research effort started while I was a Southeastern Center for Electrical Engineering Education Fellow conducting research at Brooks Air Force Base in 1982. I was fortunate to work with my mentor, Dr. Wally Wolfe, who introduced me to this field. The objective of this research is the rigorous development of a homeomorphic neural network (system) whose basic elements rely on interconnected single neuron models and a muscle model to be developed at the sarcomere level. The neural network developed quantitatively describes the role and activity of individual neurons in the neural network, and its topology (connectivity) to reflect known CNS anatomy. The linear muscle model developed by me and my coworkers is the first model to have the static and dynamic characteristics of muscle and corrects errors made by early investigators in the beginning of the 20th century that have persisted into the early 1990s. The neural network model is based on a time-optimal control of saccades and neuron behavior. Recently, I have authored with others a series of papers on a new linear muscle fiber model for neural control of saccades, a neuron-based time-optimal controller of horizontal saccadic eye movements, and a physiological neural controller of a muscle fiber oculomotor plant in horizontal monkey saccades. Our current research efforts involve a 3D model of the oculomotor plant and a neural network for visual saccades, auditory saccades and their neural network, a 3D smooth pursuit model for visual and auditory eye movements, and an inexpensive and portable device for the detection and localization of traumatic brain injury.
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