Yong-Jun Shin, M.D., Ph.D.
Modeling intelligent features (adaptation and robustness) of biological systems, Cloud-enabled smart bioMEMS, Internet of Cells (IoC), Internet of Microscopes (IoM)
UCONN Computational and Systems Medicine Lab (CSMLab) http://csml.uconn.edu
260 Glenbrook Road, Unit 3247
University of Connecticut
Storrs, CT 06269-3247
Office Phone: (860) 486-7153
MD, Seoul National University College of Medicine
MS PhD (Electrical Engineering), University of Texas at Dallas
PostDoc (Electrical and Computer Engineering), Cornell University
All living systems, including microscopic cells, live in environments that are uncertain, dynamically-changing, and even hostile. However, it is remarkable that these systems survive and achieve their goals by exhibiting intelligent features such as adaptation and robustness. Using engineering principles and tools (e.g., control and estimation theory), which can simulate “smart” behaviors of individual cells coupled at the molecular level, my lab is developing Engineering-as-a-Service (EaaS) for studying intelligent cell population dynamics. EaaS is a community-based service-oriented architecture (SOA) that provides modular, interoperable, and reusable computational components as web services for the study of complex intelligent systems. Experimental validation is critical for any modeling and my lab is also developing a new experimental platform for in silico feedback control of protein levels in multiple cells, which can be integrated with digital microfluidics/bioMEMS (MicroElectroMechanical System) for massively-parallel high-throughput experimentation. It is hoped that eventually new medical diagnosis and treatment methods can be designed and tested using this platform.
Information on current projects can be found on my website.