Professor, UConn Biomedical Engineering
Director, UConn Center for Biomedical and Bioengineering Innovation (CBBI)

Research Interests:
Biomedical optics and instrumentation, computational imaging and sensing, microscopy and ptychography, optofluidics and chip-scale imaging.

 Email: guoan.zheng@uconn.edu
Lab webpage: https://smartimaging.uconn.edu/
Personal webpage: https://sites.google.com/view/smartimaging/

Address:
260 Glenbrook Road, Unit 3247
Bronwell 217, Storrs, CT 06269-3247

Office: (860) 486-6973
Fax: (860) 486-2500

Education:
B.S. in Electrical Engineering, Zhejiang University, 2007
M.S. in Electrical Engineering, California Institute of Technology, 2008
Ph.D. in Electrical Engineering, California Institute of Technology, 2013 

Research summary:
The research at the Smart Imaging Laboratory is focused on the development of advanced imaging and sensing tools to tackle measurement challenges in the fields of biology, medicine, and metrology. The PI, Dr. Zheng, is recognized for his pioneering work on Fourier ptychography, which has been adopted worldwide and become a standard tool in microscopy imaging. Notably, this technique also became a chapter in “Introduction to Fourier Optics (4th edition)”, the most widely-read textbook on Fourier optics.

Dr. Zheng’s contributions have resulted in the publication of one book and more than 130 peer-reviewed articles, including those in top-tier journals such as Nature Photonics, Nature Reviews Methods Primers, Nature Reviews Physics, Nature Communications, Nature Protocols, eLight, and Light: Science & Applications. His research has been cited over 14,000 times, with an h-index of 62 (Google Scholar profile). Dr. Zheng has been listed in the World's Top 2% Scientists released by Stanford University since 2020.

Dr. Zheng serves as the Senior Editor of PhotoniX, Associate Editor of Biomedical Optics Express, Deputy Editor of Advanced Imaging, Editorial Board Member of Computational Imaging and Measurement, Advisory Editor of Biophotonics Discovery, Guest Editors of Optics Express, Applied Optics, IEEE Transactions on Computational Imaging, and IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, the Chair of the Optics Study Group of the IEEE Synthetic Aperture Standards Committee, and the Co-Chair of the conference, Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences, in SPIE Photonics West. He is also an elected member of the Connecticut Academy of Science and Engineering

Selected Publications (Google Scholar Profile, cited over 14600 times, h-index of 62):

1. Ruihai Wang, Qianhao Zhao, Lars Loetgering, Frederick Allars, Zhixuan Hong, Timothy J. Pennycook, Roarke Horstmeyer, John Rodenburg, Andrew Maiden, and Guoan Zheng*, “Ptychography at all wavelengths,” Nature Reviews Methods Primers, 5(1), 68 (2025).
2. Ruihai Wang, Qianhao Zhao, Tianbo Wang, Mitchell Modarelli, Peter Vouras, Zikun Ma, Zhixuan Hong, Kazunori Hoshino, David Brady, and Guoan Zheng*, “Multiscale aperture synthesis imager,” Nature Communications, 17, (2025).
3. Ruihai Wang, Qianhao Zhao, Julia Quinn, Liming Yang, Yuhui Zhu, Feifei Huang, Chengfei Guo, Tianbo Wang, Pengming Song, Michael Murphy, Thanh D. Nguyen, Andrew Maiden, Francisco E. Robles, Guoan Zheng*, “Deep-ultraviolet ptychographic pocket-scope (DART): mesoscale lensless molecular imaging with label-free spectroscopic contrast,” eLight, 5, (2025).
4. Pengming Song, Ruihai Wang, Lars Loetgering, Jia Liu, Peter Vouras, Yujin Lee, Shaowei Jiang, Bin Feng, Andrew Maiden, Changhuei Yang, Guoan Zheng*, “Ptycho-endoscopy on a lensless ultrathin fiber bundle tip,” Light: Science and Applications, 13, 168, (2024).
5. Shaowei Jiang, Pengming Song, Tianbo Wang, Liming Yang, Ruihai Wang, Chengfei Guo, Bin Feng, Andrew Maiden, and Guoan Zheng*, “Spatial and Fourier domain ptychography for high-throughput bio-imaging,” Nature Protocols, 18, 2051-2083 (2023).
6. Chengfei Guo,Shaowei Jiang, Liming Yang, Pengming Song, Azady Pirhanov, Ruihai Wang, Tianbo Wang, Xiaopeng Shao, Qian Wu, Yong Ku Cho, Guoan Zheng*, “Depth-multiplexed ptychographic microscopy for high-throughput imaging of stacked bio-specimens on a chip,” Biosensors and Bioelectronics, 115049 (2023).
7. (Cover paper) Guoan Zheng*, Cheng Shen, Shaowei Jiang, Pengming Song, and Changhuei Yang*, “Concept, implementations and applications of Fourier ptychography,” Nature Reviews Physics, 3, 207-223 (2021).
8. (Editor’s pick) Pengming Song, Shaowei Jiang, Tianbo Wang, Chengfei Guo, Ruihai Wang, Terrance Zhang, and Guoan Zheng*, “Synthetic aperture ptychography: coded sensor translation for joint spatial-Fourier bandwidth expansion,” Photonics Research, 10(7), 1624-1632 (2022).
9. (Cover paper) Shaowei Jiang, Chengfei Guo, Pengming Song, Tianbo Wang, Ruihai Wang, Terrance Zhang, Qian Wu, Rishikesh Pandey, and Guoan Zheng*, “High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner,” Lab on a Chip, 22, 2657-2670,(2022).
10. (Cover paper, ACS Editors’ choice) Shaowei Jiang, Chengfei Guo, Tianbo Wang, Jia Liu, Pengming Song, Terrance Zhang, Ruihai Wang, Bin Feng, and Guoan Zheng*, “Blood-coated sensor for high-throughput ptychographic cytometry on a Blu-ray disc,” ACS Sensors, 7(4), 1058-1067 (2022).
11. (Cover paper) Shaowei Jiang, Chengfei Guo, Pengming Song, Niyun Zhou, Zichao Bian, Jiakai Zhu, Ruihai Wang, Pei Dong, Zibang Zhang, Jun Liao, Jianhua Yao, Bin Feng, Michael Murphy, and Guoan Zheng*, “Resolution-Enhanced Parallel Coded Ptychography for High-Throughput Optical Imaging,” ACS Photonics, 8(11), 3261-3271 (2021).
12. Guoan Zheng*, Roarke Horstmeyer and Changhuei Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nature Photonics, 7, 739–745 (2013).