Marja M, Hurley, M.D.
Professor of Medicine and Orthopedics
Member Institute of Systems Genomics
Office Phone: (860) 679-2830
Medicine, Orthopedic Surgery
The Hurley laboratory currently examines 1) molecular mechanisms by which members of the fibroblast growth factor (FGF) and FGF receptor families moduulate fracture repair, bone remodeling and disorders of bone and phosphate homeostasis. FGF2 knockout and FGF2 transgenic mice are utilized to elucidate the role of FGF2 in disorders of bone including osteoporosis and hypophosphatemic rickets. 2) The epigenetic mechanism by which the nuclear localized high molecular weight isoforms of FGF2 mediates growth-plate abnormalities and osteoarthropathy. 3) Role of the microbiome in sickle cell bone disease.