Guoan Zheng, Ph.D.

United Technologies Corporation (UTC) Associate Professor
Research Interests: Biomedical optics and instrumentation, computational imaging and sensing, microscopy and ptychography, optofluidics and chip-scale imaging.
Lab webpage:
Personal webpage:
260 Glenbrook Road, Unit 3247
Bronwell 217, Storrs, CT 06269-3247
Office Phone: (860) 486-6973
Office Fax: (860) 486-2500

B.S. in Electrical Engineering, Zhejiang University, 2007
M.S. in Electrical Engineering, California Institute of Technology, 2008
Ph.D. in Electrical Engineering, California Institute of Technology, 2013

Research summary:

The research at the Smart Imaging Laboratory is focused on the development of advanced imaging and sensing tools to tackle measurement challenges in the fields of biology, medicine, and metrology. Led by Prof. Guoan Zheng, the team has contributed significant advancements in ptychography and computational imaging. A notable achievement is the development of Fourier ptychography, a technique that establishes a new standard in computational microscopy across numerous laboratories worldwide. This innovation has also been included as a chapter in Prof. Joseph Goodman’s renowned textbook, “Introduction to Fourier Optics (4th edition).” Currently, the laboratory’s research endeavors span various areas, including ptychographic endoscopy, high-throughput microscopy and screening, super-resolution imaging, lensless coded ptychographic microscopy, Fourier ptychography, optical physiology, and label-free imaging. Since its inception in 2013, the laboratory has been supported by NIH, NSF, Connecticut Innovations, the UConn Research Excellence Program, and partnerships with multiple industry leaders.

Selected Publications (*: corresponding author):
Google Scholar Citations Link (cited over 11000 times, h-index of 54 as of Feb 2024)


  1. Shaowei Jiang, Pengming Song, Tianbo Wang, Liming Yang, Ruihai Wang, Chengfei Guo, Bin Feng, Andrew Maiden, and Guoan Zheng*, "Spatial and Fourier domain ptychography for high-throughput bio-imaging," Nature Protocols, 18, 2051-2083 (2023).
  2. Chengfei Guo,Shaowei Jiang, Liming Yang, Pengming Song, Azady Pirhanov, Ruihai Wang, Tianbo Wang, Xiaopeng Shao, Qian Wu, Yong Ku Cho, Guoan Zheng*, “Depth-multiplexed ptychographic microscopy for high-throughput imaging of stacked bio-specimens on a chip,” Biosensors and Bioelectronics, 115049 (2023).
  3. (Editor’s pick) Pengming Song, Shaowei Jiang, Tianbo Wang, Chengfei Guo, Ruihai Wang, Terrance Zhang, and Guoan Zheng*, “Synthetic aperture ptychography: coded sensor translation for joint spatial-Fourier bandwidth expansion,” Photonics Research, 10(7), 1624-1632 (2022).
  4. (Cover paper) Shaowei Jiang, Chengfei Guo, Pengming Song, Tianbo Wang, Ruihai Wang, Terrance Zhang, Qian Wu, Rishikesh Pandey, and Guoan Zheng*, “High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner,” Lab on a Chip, 22, 2657-2670,(2022).
  5. (Cover paper, ACS Editors’ choice) Shaowei Jiang, Chengfei Guo, Tianbo Wang, Jia Liu, Pengming Song, Terrance Zhang, Ruihai Wang, Bin Feng, and Guoan Zheng*, “Blood-coated sensor for high-throughput ptychographic cytometry on a Blu-ray disc,” ACS Sensors, 7(4), 1058-1067 (2022).
  6. (Cover paper) Pengming Song, Chengfei Guo, Shaowei Jiang, Tianbo Wang, Patrick Hu, Derek Hu, Zibang Zhang, Bin Feng, and Guoan Zheng*, “Optofluidic ptychography on a chip,” Lab on a Chip, 21(23), 4509-4726 (2021).
  7. Shaowei Jiang, Chengfei Guo, Zichao Bian, Ruihai Wang, Jiakai Zhu, Pengming Song, Patrick Hu, Derek Hu, Zibang Zhang, Kazunori Hoshino, Bin Feng, Guoan Zheng*,  “Ptychographic sensor for large-scale lensless microbial monitoring with high spatiotemporal resolution,” Biosensors and Bioelectronics196, 113699 (2022).
  8. (Cover paper) Shaowei Jiang, Chengfei Guo, Pengming Song, Niyun Zhou, Zichao Bian, Jiakai Zhu, Ruihai Wang, Pei Dong, Zibang Zhang, Jun Liao, Jianhua Yao, Bin Feng, Michael Murphy, and Guoan Zheng*, "Resolution-Enhanced Parallel Coded Ptychography for High-Throughput Optical Imaging," ACS Photonics, 8(11), 3261-3271 (2021).
  9. (Cover paper) Guoan Zheng*, Cheng Shen, Shaowei Jiang, Pengming Song, and Changhuei Yang*, “Concept, implementations and applications of Fourier ptychography,” Nature Reviews Physics, 3, 207-223 (2021).
  10. Guoan Zheng*, Roarke Horstmeyer and Changhuei Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nature Photonics, 7, 739–745 (2013).