Research Summary:

The research of the Smart Imaging Laboratory is focused on the development of novel imaging/sensing tools to tackle measurement problems in biology, medicine, and metrology. The major techniques that are under development include gigapixel microscopy platforms, super-resolution florescence imaging approaches, 3D tomography imaging, ePetri dish and related lab-on-a-chip platforms, surface-plasmon-enabled imaging devices, and other novel imaging techniques. In particular, the Fourier Ptychography approach developed by our group represents a new way of tackling microscopy by transforming a physical optical problem to a computational problem. Through this reduction, we can push the performance of standard imaging systems beyond their physical limitations. We have demonstrated the use of Fourier ptychography for high-resolution gigapixel imaging, quantitative phase imaging, spectral multiplexing, adaptive imaging, super-resolution fluorescence imaging, 3D holographic imaging, incoherent photographic imaging, and remote sensing. More information about current projects can be found at: Smart imaging lab at UConn: https://sites.google.com/site/gazheng/

Honors and Awards:

• Caltech Demetriades Thesis Prize, 2013
• Phi-Tau-Phi Scholarship, Phi-Tau-Phi Scholastic Honor Society, 2012
• Lemelson-MIT Caltech Student Prize, Kirsch Auditorium, MIT Stata Center, 2011

Selected Publications:

Google Scholar Citations Link

1. Guoan Zheng, Xiquan Cui, and Changhuei Yang, “Surface-wave-enabled darkfield aperture for background suppression during weaksignal detection,” Proceedings of the National Academy of Science (PNAS), 107 (60), 9043-8 (2010).
2. Guoan Zheng, Seung Ah Lee, Yaron Antebi, Micheal B. Elowitz, and Changhuei Yang, “The ePetri dish, an on-chip cellimaging platform based on subpixel perspective sweeping microscopy (SPSM),” Proceedings of the National Academy of Sciences (PNAS), 108, 16889-94 (2011).
3. Guoan Zheng, Roarke Horstmeyer and Changhuei Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nature Photonics, 7, 739–745 (2013).
4. Guoan Zheng, “Breakthroughs in Photonics 2013: Fourier Ptychographic Imaging,” IEEE Photonics Journal, 6, 1-7 (2014).
5. Siyuan Dong, Roarke Horstmeyer, Radhika Shiradkar, Kaikai Guo, Xiaoze Ou, Zichao Bian, Huolin Xin, and Guoan Zheng, “Aperture-scanning Fourier ptychography for 3D refocusing and super-resolution macroscopic imaging,” Optics Express, 22 (11), 13586-13599, (2014)